Resveratrol powder in bulk resveratrol skin

What Is Resveratrol

Resveratrol, a non-flavonoid polyphenol organic compound identified by its chemical formula C14H12O3, is a naturally occurring antitoxin produced by various plants in response to environmental stimuli. This bioactive nutrient supplement can be found abundantly synthesized in grape leaves, grape skins, and serves as a key component in wine and grape juice, contributing to their health-promoting properties. Notably, resveratrol exhibits high oral bioavailability, being easily absorbed and later excreted through urine and stool following metabolism.

In vitro studies and animal experiments have demonstrated that resveratrol boasts a range of beneficial effects, including potent antioxidant, anti-inflammatory, anticancer, and cardiovascular protective activities, which categorize it as a sought-after ingredient in Natural Extracts and Nutrient Supplements.

Moreover, the recognition of resveratrol extends beyond the health and wellness sector; it has been included in the Catalogue of Used Cosmetic Raw Materials (2015 edition) issued by the former State Food and Drug Administration of China with serial number 01152. Resveratrol also garners international acclaim, having been listed as "one of the 100 most effective anti-aging substances" by the American Anti-Aging Canon, thereby affirming its status as a valuable constituent in Natural Food Healthy Products and Chinese herb extract for promoting overall health and longevity.

The activator of ation regulation 2 homolog1 (SIRT1) can simulate calorie restriction (CR) anti-aging reaction and participate in the regulation of the mean life span of organic organisms. As a strong inducer of SIRT1, CR can increase the expression of SIRT1 in brain, heart, intestine, kidney, muscle, fat and other organs and tissues. CR can cause physiological changes to delay aging and prolong life, the most significant of which can be extended by 50%. Studies have shown that resveratrol can extend the life of yeast, nematodes, fruit flies and lower fish.

· Anti-tumor and anti-cancer

Resveratrol has significant inhibitory effect on hepatocellular carcinoma, breast cancer, colon cancer, gastric cancer, leukemia and other tumor cells. Some scholars have confirmed that resveratrol has obvious inhibitory effect on melanoma cells by MTT method and flow cytometry.

It has been reported that resveratrol can enhance cancer radiation therapy, play a "1+1>2" effect, and effectively inhibit the role of cancer stem cells. But so far, due to the complexity of the anti-tumor mechanism of resveratrol, researchers have not reached a consensus on its mechanism of action.

· Anti-cancer mechanism

Resveratrol is an antioxidant, anti-cardiovascular disease, anti-cancer, anti-bacterial, anti-platelet aggregation, anti-bacterial, anti-aging, and can block the pathways of apoptosis, NF-κB, PI3K/Akt, MAPK, and anti-tumor. It is a plant antitoxin and anti-tumor sensitising agent, which exists in white veratrol, Polynesia, grape, peanut, pine, mulberry, etc. It can play a preventive and therapeutic role in the initiation, occurrence and spread of tumors, promote the expression of apoptosis suppressor protein (IAPs) and tumor necrosis factor-related apoptosis inducing ligand (TRAIL), induce the degradation of surviatin, and down-regulate the levels of anti-apoptosis proteins Bcl-xL, Mcl-1, ERK1/2 and heat shock protein 70. Increased expression of thrombopoietic proteins Bax, Bak, Bid, Bad and sirtuinl (activated FoxO and p53) induced apoptosis of tumor cells. Resveratrol can inhibit TNF-A-induced IrB, inhibit NF-B phosphorylation and activation, activate histone deacetylase, and can be anti-inflammatory, anti-proliferation and anti-cancer. Resveratrol inhibits NF-B inducers such as: Phobolate, lipopolysaccharide, neuroamide and IL-1β can inhibit the production of reactive oxygen species by COX-2, inhibit PI3K/Akt and ERK1/2 pathways, promote the synthesis of p53, Rb, FoxO, TRAIL, DR4, DR5, p21 and p27, and mediate cell apoptosis. Reduce the synthesis of E2F, cyclin, CDK, AP-1, Egrl, EGF and inhibit cell proliferation.

· Prevention and treatment of cardiovascular diseases

Epidemiological studies have found that the "Frenchparadox" phenomenon, that is, the incidence and mortality of cardiovascular diseases are significantly lower than those in other European countries despite the daily intake of large amounts of fat, may be related to the daily consumption of wine, and resveratrol may be its main active protective factor. Studies have shown that resveratrol can regulate the level of cholesterol in the blood through the combination of estrogen receptors in the human body, inhibit the formation of platelets and blood clots adhering to the blood vessel wall, thus inhibiting and reducing the occurrence and development of cardiovascular diseases and reducing the risk of cardiovascular diseases.

· Other functions

Resveratrol also has antibacterial, antioxidant, immunomodulatory, antiasthmatic and other biological activities. Resveratrol is highly sought after because of its various biological activities.